Michigan Center for Infectious Disease Threats at University of Michigan

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Sep 6, 2024

Authors: Yvonne Huang,

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Using the SPIROMICS study MCIDT affiliate Yvonne Huang found that a more diverse baseline airway microbiota is associated with better COPD-related outcomes when compared to those with less diversity. Specific species linked to differing outcomes as well

Key Terms: Airway, COPD, Microbiota

Box plot and scatter plots indicating that Baseline airway microbiome features associated with longitudinal lung function outcome. (A) Baseline sputum α-diversity between the trajectory groups: stable/improved, decline, and rapid decline. (B) Bacterial genera associated with categorical FEV1 trajectory using linear discriminant analysis effect size (27). LDA = linear discriminant analysis score from linear discriminant effect size analysis (LEfSe)
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