Publications - University of Michigan Michigan Center for Infectious Disease Threats

Graphical Summary of results showing their mouse model. Summary of results. (A) Comparison of survival of WT C57BL/6 mice and PKR-TKO mice upon infection with WT MAV-1 at ~1 LD50 (102 PFU). “X” indicates knockout of PKR in the PKR-TKO mice. Data based on Fig. 3 and Table 1. (B) Comparison of survival of WT and PKR-TKO mice upon infection by mutant E4orf6TMC2 virus at the maximum dose, 107 PFU. The E4orf6 change of three amino acids in the Cul2-binding site is indicated by the “X” on the mutant virus

Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis

February 10, 2025

Forest plot for the primary outcome of clinical success across key subgroups. Adjusted ORs were calculated after controlling for age (≥65 years or

Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study

January 21, 2025

graphical abstract of the study, highlighting - Staggered TLR and IFNAR signaling guide MRSA-induced metabolic remodeling in macrophages - Infection-induced NO, disrupts the respiratory chain modulating IL-1b and IFN-b production - Histone lactylation represses Nos2 and limits NO, -driven IFNb production - Chronic type I IFN blunts histone lactylation

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

October 1, 2024

Box plot and scatter plots indicating that Baseline airway microbiome features associated with longitudinal lung function outcome. (A) Baseline sputum α-diversity between the trajectory groups: stable/improved, decline, and rapid decline. (B) Bacterial genera associated with categorical FEV1 trajectory using linear discriminant analysis effect size (27). LDA = linear discriminant analysis score from linear discriminant effect size analysis (LEfSe)

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

September 6, 2024

Image depicting the mouse model used for this experiment and then scatter plots of cell counts

RSV enhances Staphylococcus aureus bacterial growth in the lung

August 23, 2024

image of a stethescope on a doctor's chart

Characteristics of Patients Hospitalized in Rural and Urban ICUs From 2010 to 2019

August 12, 2024

Graphical abstract of the analysis of cell types and the impacts of host factors on viral infections

iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection

August 6, 2024

Graph depicting the odds of infection depending on your functional dependency as well as comparing the contamination rate with each kinds task they are depndent on someone for and ranking them

Functional dependence as a contributing factor for patient hand contamination by multi-drug resistant organisms (MDROs) in acute care

July 24, 2024

Image depicting the steps to create the Virus inactivation rate constant estimation model and a mock up of the data output

Linear Mixed Model of Virus Disinfection by Free Chlorine to Harmonize Data Collected across Broad Environmental Conditions

July 17, 2024