Michigan Center for Infectious Disease Threats at University of Michigan

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

Oct 1, 2024

Authors: Beth Moore, Teresa O’Meara, Jonny Sexton,

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MCIDT Affiliate Mary O’Riordan, as well as Teresa O’Meara and Jonny Sexton, found that the type I interferon (IFN) orchestrates the metabolic and inflammatory responses in macrophages during MRSA infection, guiding potential therapeutic applications

Key Terms: Type I Interferon, MRSA, Macrophages

 

graphical abstract of the study, highlighting - Staggered TLR and IFNAR signaling guide MRSA-induced metabolic remodeling in macrophages - Infection-induced NO, disrupts the respiratory chain modulating IL-1b and IFN-b production - Histone lactylation represses Nos2 and limits NO, -driven IFNb production - Chronic type I IFN blunts histone lactylation
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