Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements

Sep 14, 2023 | News, Research

Ribonucleic acid strands consisting of nucleotides important for protein bio-synthesis - 3d illustration

Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements

Published on 8 September 2023 in the Journal of Virology

MCIDT Affiliate Dr. Alice Telesnitsky’s research shows HIV-1 employs diverse transcription start sites (TSSs) to craft two RNA 5´ isoforms with radically different structures and each with specific functions shaping the virus’s pathogenesis

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